Abstract：Objective: To explore the value of contrast-enhanced ultrasonography(CEUS) in quantitative evaluation of rabbit’s cortex hemodynamic changes after renal ischemia reperfusion injury(RIRI). Methods: All the 54 rabbits were randomly divided into control group and different time groups at 2 h, 16 h, 24 h, 3 d, 5 d after ischemia reperfusion. Using CEUS to observe the pattern of rabbits’ renal perfusion and perfusion peak time(TTP), curve rising slope rate(β), amplitude of peak intensity(A), and area under the curve(AUC). And researched the relativity between quantitative evaluation of rabbit’s cortex hemodynamics by CEUS and renal pathologic changes. Result: Compared with control group, the TTP and AUC extend, β decreased after RIRI(P<0.05). TTP and β had difference in RIRI groups, while the most significant changes happened at 3 d after reperfusion(P<0.01). Compared with control group, the A decreased at 16 h, 24 h, 3 d after RIRI(P<0.05), while the most significant changes happened at 3 d after reperfusion(P<0.01). Conclusion: CEUS combined with quantitative analysis can catch early the rabbit’s cortex hemodynamic changes after RIRI. Renal cortex microcirculation suffered the most severe damage at 3 d after RIRI. It would get better while passed through the crisis. CEUS can reflect these changes sensitively.
2015, Vol. 26 
