Abstract：Objective: To investigate the related factors of pancreatic volume(PV) and pancreatic fat content(PFC) in type 1 diabetes mellitus(T1DM) patients. Methods: We retrospectively reviewed 92 patients who were diagnosed as T1DM in our hospital. And the patients were divided into three groups according to the duration of diabetes(Group A<60 months, 51 patients; Group B 60～<120 months, 20 patients; Group C≥120 months, 21 patients). The difference and correlation among PV, pancreatic fat volume(PFV), PFC, total abdominal adiposity(TA), visceral adiposity(VA), superficial adiposity(SA), VA/SA, body mass index(BMI), duration of diabetes(months), triglyceride(TG), high density lipoprotein(HDL-C), total cholesterol(TC), low density lipoprotein(LDL-C), blood pressure(systolic and diastolic pressure), blood sugar(OGTT fasting and 2 hours after meal), insulin(fasting, 1, 2, 3 hours after meal), C-peptide(fasting, 1, 2, 3 hours after meal) and glycosylated hemoglobin A1c(HbA1c) were analyzed. Results: There was significant difference in age, TG, C-peptide(fasting, 1 hour after meal), PFV and PFC among group A～C(P<0.05); C-peptide(fasting) and PV between group A and group B; Age, C-peptide(fasting, 1 hour after meal), TG, PFV, PFC and VA between group A and group C; TG, PFV and PFC between group B and group C(P<0.05). PV was not correlated with age, C-peptide or duration of diabetes. PFV was positively correlated with VA and positively correlated with BMI. PFV was positively correlated with HDL-C. PFC was positively correlated with duration of diabetes. Conclusion: The change of PV and PFC in T1DM had its own characteristics. PV was not correlated with pancreatic external secretion function. PV decreased in patients with a diabetic duration of more than 5 years and the trend was less obvious in patients with duration of 5～10 years, which was in step with C-peptide. PFC increased gradually with duration of diabetes, which was extremely obvious in patients with duration of diabetes more than 10 years and was in step with TG. PFC was positively correlated with VA and HDL-C. The change of PFC was earlier than VA. C-peptide was correlated with age and BMI. We inferred that the increase of PFC may have some correlation with the function of pancreas cell, which is different from type 2 diabetes mellitus whose PFC is correlated with insulin resistance. Further study is needed to verify this conclusion.
崔 斌;祝安惠;张晓锦. 1型糖尿病患者胰腺体积和胰腺脂肪含量的相关性研究[J]. , 2015, 26(6): 408-412.
CUI Bin;ZHU An-hui;ZHANG Xiao-jin. The correlation of pancreatic volume and pancreatic fat content in type 1 diabetes mellitus. , 2015, 26(6): 408-412.
2015, Vol. 26 
