Abstract：Objective: To assess the clinical application value of dynamic susceptibility contrast(DSC) MR perfusion and 2D-Multivoxel 1H MR spectroscopy in the differentiation of high-grade gliomas and cerebral metastases. Methods: Retrospective analysis all patients’ data who with histopathologic diagnosis of high-grade gliomas(n=16) and metastases(n=9) underwent DSC-MR perfusion imaging and 2D-Multivoxel 1H MR spectroscopy before surgery. The data were analyzed retrospectively. The ratios of relative cerebral blood volume(rCBV) were measured in the regions of tumor, peritumoral and marginal regions with T2 hyperintensity respectively. Simultaneously, the interesting voxel Cho/NAA, Cho/Cr, NAA/Cr ratios were calculated in the peritumoral area and in the maximum perfusion area of tumor in the MRS slice. The difference of the these data have been analysed statistically. Result: There are no significant difference of rCBV in the maximum perfusion area of tumor and marginal zone with T2 hyperintensity between high-grade glomas group and metastases group. But, the value of rCBV of high-grade glomas group is significantly higher than metastases group(P＝0.023). The results of 2D-Multivoxel 1H MR spectroscopy demonstrated that the ratio of Cho/NAA, Cho/Cr in the maximum perfusion area of high-grade glomas group tumor and the Cho/NAA in the peritumoral area were more higher than those of the metastases group significantly. Conclusion: DSC-MR perfusion imaging and 2D-Multivoxel 1H MR spectroscopy can offer the information of angiogenesis and metabolin in tumor and peritumoral area, so these techniques will be usefull in differentiating metastases form high-grade gliomas.
2010, Vol. 21 
