The imaging characteristics of hereditary spastic paraplegia with thin corpus callosum
LI Xiao-dong1, GAO Pei-hong2, WANG Gui-bin2, CHE Feng-yuan2, WANG Jin-liang2, GAO Nai-yong2, WANG Gui-ling2
1. Department of Radiology, General Hospital of Tianjin Medical University, Tianjin 300052, China;2. Linyi People’s Hospital, Linyi Shandong 276003, China
Abstract：Objective: To analyze the imaging characteristics of hereditary spastic paraplegia with thin corpus callosum(HSP-TCC), so as to get a better understanding of the disease. Methods: Three patients from the same family with HSP-TCC were reported with reviewing of the literature. Results: Thin corpus callosum, long T2 signal in the thinning cervical and thoracic spinal cord were seen. Diffused unspecific white matter lesions with mild brain atrophy, were also seen in the three HSP-TCC cases of this group. Conclusion: The central nervous system may be affected extensively by HSP-TCC, characteristic MRI signs including thin corpus callosum, long T2 signal in the white matter around lateral ventricle and in the spinal cord, atrophy and abnormal signal of the spinal cord, as well as subsequent mild or moderate brain atrophy.
2010, Vol. 21 
