Abstract:Objective: To explore the characteristics of interatrial septal aneurysm(IASA) complicated with anomalies and its treatment. Methods: Thirty-two inpatients with IASA and complicated with anomalies and 20 outpatients with isolated IASA were identified in our department. In 20 outpatients(4 male, 16 female) with isolated IASA, 8 patients accompanies with patent foramen ovale(PFO), ages ranged from 3.5~54 years old, with an average of 36.38±15.15. In 32 inpatients(8 male, 24 female) with IASA complicated with anomalies, ages ranged from 3 months to 61 years old, with an average of 31.88±18.28. Length of IASA, height of IASA, diameter of right ventricle, and cardiac function tests of the left ventricle were evaluated by electrocardiogram, X-ray, transthoracic echocardiography(TTE), transesophageal echocardiography(TEE). The patients with IASA and complicated with anomalies underwent catheterization and interventional therapy or surgery. Results: In 32 patients with IASA and complicated with anomalies, 16 patients(50%) underwent surgery and 16 had interventional therapy. Multiple atrial septal defects(ASDs) were found, 7 patients underwent surgery and 6 underwent interventional therapy. Conclusion: The commonest anomalies complicated with IASA are ASDs, which are often multiple. TTE and TEE are the key methods to select patients for interventional therapy or surgical treatment.