Abstract：Objective: To approach the clinical application value of correspondance quantitative analysis with 3.0T magnetic resonance spectroscopy(1H-MRS) in grading cerebral glioma before operation. Methods: Thirty-two patients with cerebral glioma confirmed by pathological results were performed with 1H-MRS on GE 3.0T magnetic resonance system. The spectral line in the solid area of tumour, peritumor edematous area and normal-area of the opposite side were observed with 1H-MRS. Cho/Cr, NAA/Cr, Cho/NAA, Cho/nCho, Lac/Cr were analyzed. The results of 1H-MRS were compared with the results of pathology. Another 11 subjects were normal control. Results: There were significant differences in Cho/Cr, NAA/Cr, Cho/NAA between solid area of glioma and normal area of the opposite side(2.10±1.04, 0.84±0.44, 2.05±0.70 and 0.87±0.13, 1.43±0.14, 0.61±0.10 respectively). There were significant differences in Cho/Cr, NAA/Cr, Cho/NAA, Cho/nCho, Lac/Cr between solid area in the low grade glioma group and that in the high grade glioma group that is(1.58±0.63, 0.96±0.57, 1.74±0.61, 1.04±0.81, 1.58±0.10 and 2.62±1.45, 0.78±0.31, 3.35±0.89, 2.14±1.77, 2.61±2.75 respectively)(P<0.05). There were also significant differences in Cho/Cr, NAA/Cr, Cho/NAA, Cho/nCho(i.e. 1.43±0.32, 0.82±0.45, 1.22±0.19, 1.23±0.36 and 2.21±0.49, 1.12±0.23, 2.09±0.82, 1.47±1.13) between edematous area in the low grade glioma group and that in the high grade glioma group(P<0.05). Cho/Cr, Cho/NAA, Cho/nCho, Lac/Cr(r=0.42, 0.62, 0.41, 0.26) of solid area of tumor was of positive correlation with the grade of tumor, and NAA/Cr(r=-0.35) was of negative corretation. The correlative coefficient of Cho/NAA(r=0.62) was the maximum and had maximal dependability with grade of tumor. Conclusion: 1H-MRS had very important clinical application value in providing diagnostic support for grading of cerebral glioma before operation.
2011, Vol. 22 
