Abstract：Objective: To study the imaging features of brain diffuse axonal injury(DAI) by magnetic resonance spectroscopy(MRS), and explore the value of MRS in the diagnosis of DAI and severity assessment. Materials and Methods: Thirty patients with DAI(DAI group) and 10 healthy volunteers(control group) undertook 1H-MRS scanning, to assess the metabolite levels of N-acetyl aspartic acid(NAA), choline(Cho), creatine(Cr), combined with Glasgow coma scale(GCS) and Glasgow outcome scale(GOS) score for correlation analysis. Results: Compared with control group, NAA decreased, Cho increased, NAA/Cho, NAA/Cr value decreased and Cho/Cr value increased in DAI group. The change of NAA/Cr, NAA/Cho, Cho/Cr value showed correlation with GCS and GOS in patients with DAI. Conclusion: MRS can quantitatively measure the brain tissue metabolism of patients with DAI, showing important value for the diagnosis and prognosis evaluation of the severity of DAI.
2014, Vol. 25 
