Abstract：Objective: To investigate the relationship between the MRS and the Ki-67, bcl-2 expression of human astrocytoma. Methods: Fifty-two patients of astrocytoma proved by surgery and pathology were included. MRS was performed in all the patients. After surgical operation, the specimen was examined for Ki-67 and bcl-2. The NAA/Cho, Cho/Cr and NAA/Cr were recorded and the relationship with tumor grade was analyzed. The relationship between the above indices and Ki-67, bcl-2 were investigated respectively. Results: There was significant correlation between NAA/Cr, Cho/Cr, NAA/Cho and the pathological grading of astrocytoma. Positive expression of Ki-67 and bcl-2 in astrocytoma. Positve expression of Ki-67, bcl-2 increased with increasing clinicopathologic grades(r=0.600, P<0.01). The Cho/Cr was strongly positively correlated with expression of bcl-2 and Ki-67(r=0.736, P<0.01; r=0.809, P<0.01 respectively). The NAA/Cho was markedly negative correlated with the expression of bcl-2(r=-0.253, P<0.01), and had markedly negative correlation with Ki-67(r=-0.501, P<0.01). The NAA/Cr of astrocytoma was negatively related with the expression of bcl-2(r=-0.369, P<0.01) and Ki-67(r=-0.416, P<0.01). Conclusion: MRS can reflect the protein manifestation of Ki-67 and bcl-2 of astrocytoma noninvasively, being helpful in the preoperative assessment of apoptosis, metabolic information, reproductive activity, invasive activity and can predict prognosis of astrocytomas. The Cho/Cr, NAA/Cho reflected pathologic grade of astrocytoma relatively steadily. The Cho/Cr and NAA/Cho are more useful than NAA/Cr.
苗 红;刘文源;宋福林. 脑星型细胞瘤磁共振波谱与肿瘤细胞的Ki-67、bcl-2相关性研究[J]. , 2011, 22(6): 389-393.
MIAO Hong;LIU Wen-yuan;SONG Fu-lin. MR spectroscopy of human astrocytoma and the correlation with the expression of Ki-67 and bcl-2. , 2011, 22(6): 389-393.
2011, Vol. 22 
