Abstract：Objective: To explore changes of metabolite levels in the occipital lobe and cerebellum for patients with vertebral-basilar insufficiency(VBI) by magnetic resonance spectroscopy(MRS). Methods: The study group consisted of nine patients diagnosed with VBI by clinical and MRA methods. Seven age-matched healthy subjects were recruited in the control group. MRS by multi-voxel chemical shift imaging was performed. The metabolite ratios of occipital lobe and cerebellum involving NAA/Cr, NAA/Cr2, Cho/Cr, Cho/Cr2 and NAA/Cho were estimated. The Mann-Whitney U test was performed to compare the differences between the two groups. The appearance of Lac peak was noted between two groups and Fisher's exact test was performed to compare the differences. Results: There was no statistical difference for the ratios of NAA/Cr2, Cho/Cr2, NAA/Cho in occipital lobe(P>0.05). The ratio of NAA/Cr in cerebellum with VBI was found decreased compared to normal control subjects(0.83±0.15 vs 0.98±0.14, P=0.043). There was no statistical difference for the ratios of NAA/Cr2, Cho/Cr2, NAA/Cho in cerebellum(P>0.05). Lac peaks were detected in the cerebellum in four VBI cases and in the occipital lobe in one VBI case. and no Lac peak was detected in the control group with statisticaldifference(P=0.034). Conclusion: MRS is a useful tool for evaluation of major changes of metabolite levels in brain and may contribute to evaluate the damage caused by VBI biochemically.
贺春妮;李 军. 磁共振波谱成像对椎基底动脉供血不足的应用价值[J]. , 2015, 26(5): 359-361.
HE Chun-ni;LI Jun. Application value of magnetic resonance spectroscopy in vertebrobasilar blood supply insufficiency. , 2015, 26(5): 359-361.
2015, Vol. 26 
