Abstract：Objective: To investigate the diagnostic accuracy of magnetic resonance spectroscopy(MRS) in prostate cancer(PCa) and its correlation with Gleason score by making a comparative study of prostate MRS and the corresponding pathological section. Methods: Radical perineal prostatectomy was performed in 5 patients with PCa. Before operation, all the patients underwent prostate MRS scanning. According to the widest cross section in prostate 3D-MRS image, the interested layer of radical prostatectomy specimens were selected and sliced. On the basis of MRS voxels, the interested layer was cut into 15~35 pieces equally. Each piece was numbered in agreement with the order of MRS voxels and made into pathological sections. The diagnosis of MRS was compared to pathological finding in the same area. The correlation between the ratio of (choline+creatine)/citrate(CC/C) and Gleason score was evaluated. According to the difference of Gleason score, the PCa regions were divided into several groups. The relationship of Gleason score and diagnostic accuracy of MRS in PCa was researched by Spearman’s rank correlation analysis. Results: 90 regions with valid pathologic diagnosis were obtained in total. Using CC/C>0.86 as the diagnostic standard, 65 cancer-affected regions and 25 cancer-free regions were diagnosed by MRS, among which the results consistent with pathologic diagnosis were 59 and 14, respectively. There was a significant positive correlation between the ratio of CC/C and Gleason score of PCa(r=0.746, P=0.000). In group 1(Gleason score=6), the diagnostic accuracy of MRS in PCa was 50%. In group 2(Gleason score=7), the diagnostic accuracy was 53.8%. In group 3(Gleason score=8), the diagnostic accuracy was 72%. In group 4(Gleason score=9) and group 5(Gleason score=10), the diagnostic accuracy was 100%. Spearman’s rank correlation analysis showed that the diagnostic accuracy of MRS in PCa was significant positively correlated to the Gleason score(r=0.223， P=0.034). Conclusion: The correlation between the diagnostic accuracy of MRS in PCa and Gleason score was significant positive. The diagnostic accuracy of MRS in PCa may gradually increased with the malignant degree of PCa.
程紫珺;赵 阳;白 玫;韩 悦;李辛子. MRS诊断前列腺癌准确率与病理切片Gleason评分的相关性研究[J]. , 2012, 23(12): 860-863.
CHENG Zi-jun;ZHAO Yang;BAI Mei;HAN Yue;LI Xin-zi. A correlation study of Gleason score and the diagnostic accuracy of MRS inprostate cancer based on pathological section. , 2012, 23(12): 860-863.
2012, Vol. 23 
