Abstract：Objective: To explore the MSCT features in patients with severe influenza A(H1N1) virus pneumonia. Methods: The 64 multi-slices spiral CT images in 20 patients diagnosed as severe influenza A(H1N1) in our hospital were studied retrospectively. Results: ①Most of the lesions in all cases were distributed diffusely and bilaterally, the others located in the middle and lower lobes. ②The CT findings including airway thickening(21/21, 100%), centrilobular nodules(12/21, 57.1%), interlobular septal thickening(9/21, 42.9%), intralobular thin reticulation and micro-nodules(3/21, 14.3%), ground-glass opacity(14/21, 66.7%), single-lobular inflammation(7/21，33.3%), large consolidation(9/21, 42.9%), airway dilatation(5/21, 23.8%). ③Pleural effusion(8/2, 38.1%); lymphadenopathy(9/21, 42.9%); pleural thickening(12/21, 57.1%); effusion of pericardium(1/21, 4.76%). ④The 9 re-examed cases, the imaging findings of the pheumonia changed quickly during the follow-up accompanied with the improvement of clinical symptoms. Three death cases showed centrilobular nodules, consolidation and ground-glass opacity. The others resolved quickly after anti-virus treatment. Conclusions: The 64-slice spiral CT findings of patients with S-OIV(H1N1) are diffuse distribution of bilateral ground-glass opacities and consolidations of lung, most of them showed abnormalities of parenchymal and interstitial tissues. Pleural effusion, lymphadenopathy and pleural thickening were observed. The increasing of ground-glass opacity and consolidation’s range could be the marker of progression of H1N1 infection.
2011, Vol. 22 
