Correlation of internal carotid artery stenosis and risk of stroke inpatients with transient ischemic attacks
XU Fang-yuan1, CHEN Shuang2, CHEN Xiao-rong1, HAN Yun-xue1, XU Ying1, MAO Yi-hu1, YU Lan1, WANG Jian-min1, YE Chun-mei1, YE Chun-yan1
1. Huashan Hospital Affiliated to Fudan University, Shanghai Baoshan Branch, Shanghai 200431, China;2. Department of Radiology, Huashan Hospital Affiliated to Fudan University, Shanghai 200040, China
Abstract：Objective: To evaluate the relationship between internal carotid artery stenosis, plaques properties and stroke occurrence in transient ischemic attacks(TIA). Materials and Methods: Conventional CT, CT angiography(CTA) and CT perfusion imaging were performed in 26 patients with clinically diagnosed TIA. The time to peak(TTP), cerebral blood flow(CBF) and cerebral blood volume(CBV) were calculated. The stenosis of carotid artery was also assessed. Results: In 26 cases with TIA, CTA showed 19 cases of internal carotid artery stenosis, mild stenosis in 7 cases(37%), moderate stenosis in 8 cases(42%), severe stenosis in 4 cases(21%). Carotid plaques in 44 places, including 9 mixed plaques, 22 calcified plaques, 7 fibrous plaques, 6 lipid plaques. Old-age incidence was obviously higher than middle-aged group(P<0.05). In 26 cases with TIA, there were 21 normal cases and 5 cases with lacunar infarction, 2 cases had multiple arteries involvement on plain CT scan. Seventeen patients had abnormal CT perfusion and 9 had normal CT perfusion in 26 cases. The TTP of affeted side (11.25±1.94)s compared with that of the contralateral side (8.64±0.96)s was significantly prolonged(t=9.418, P<0.01). The difference of the CBF and CBV was not statistically significant between both sides. Follow-up of 6 months in 3 cases had cerebral infarction. Conclusion: Cerebral apoplexy and internal carotid artery stenosis has close relationship in TIA patients. CT perfusion and CTA can provide valuable diagnostic informations for patients with TIA.
2011, Vol. 22 
