Abstract:Objective: To compare the value of ultrasonic elastography(UE) with 18F-FDG PET/CT in differentiating benign and malignant thyroid nodules. Methods: Eighty-nine patients with 115 lesions in the thyroid were retrospective studied. All the patients underwent UE and 18F-FDG PET/CT. Pathologic outcome was used as the gold diagnosis criterion. The sensitivity, specificity, accuracy of UE in diagnosing thyroid nodules were compared with 18F-FDG PET/CT. Results: Sensitivity, specificity and accuracy of UE were 87.06%, 93.05% and 72.4%, and that of 18F-FDG PET/CT were 96.55%, 66.28% and 73.91%. The accuracy of UE was higher than 18F-FDG PET/CT in differentiating benign and malignant thyroid nodules(χ2=14.29, P<0.05). Conclusion: UE has better diagnostic value than 18F-FDG PET/CT in differentiating benign and malignant thyroid nodules.