Multicenter clinical study: the use of X-ray attenuation correction to improve quantitativeanalysis precision for 99mTc-3PRGD2 lung cancer SPECT image
YANG Ai-min1, SHI Xi-min2, DAI Hao-jie3, XIN Jun4, ZHAO Xin-min5, WANG Zhe6, ZHENG Shan7, GAO Rui1, LI Mei3, MIAO Wei-bing7, ZHAO Zhou-she8, JIA Bing9, ZHU Zhao-hui2, WANG Jing5, WU Wen-kai10, LI Fang2
1.Department of Nuclear Medicine, the First Affiliated Hospital of Xian Jiaotong University, Xian 710061, China;2.Department of Nuclear Medicine, Peking Union Medical College Hospital, Beijing 100032, China;3.Department of Nuclear Medicine, Beijing Tongren Hospital, Beijing 100730, China;4.Department of Nuclear Medicine, the Affiliated Shengjing Hospital of China Medical University, Shenyang 110004, China;5.Department of Nuclear Medicine, the Fourth Hospital of Hebei Medical University, Shijiazhuang 050011, China;6.Department of Nuclear Medicine, Xijing Hospital of the Fourth Military Medical University, Xian 710032, China;7.Department of Nuclear Medicine, the First Hospital of Fujian Medical University, Fuzhou 350005, China;8.GE Healthcare(China), Beijing 100176, China;9.Medical Isotopes Research Center of Beijing University, Beijing 100191, China;10.Department of Nuclear Medicine, Cancer Hospital, Peking Union Medical College, Chinese Academy of Medical Sciences, Beijing 100021, China
Abstract：Objective: Using X-ray attenuation correction to improve a prospective, multicenter study of 99mTc-3PRGD2 SPECT image quantitative analysis precise in lung patients. Methods: 27 patients, adenocarcinoma of 23 cases and squamous cell carcinoma of 4 cases, diagnosed by pathology. Images of whole body scan and local tomography were obtained after 99mTc-3PRGD2 injection of 40 minutes intravenously. Iterative image reconstruction method was used to obtain the X-ray attenuation correction(CTAC) and no attenuation correction reconstruction(NAC) on the basis of 99mTc-3PRGD2 SPECT images. Total count of the lesions slice, total count, maximum and average count of the region of interest(ROI) were extracted individually from the slices of CTAC and NAC frames. The maximum count 38%, 42% and 48% within ROI were chosed as the threshold to measure the diameter length of CTAC and NAC image focus. Results: The results showed that after CTAC, the total count, of the focus slice was increased 2.09 times, the total count of the ROI was increased 3.32 times, maximum and mean counts and the background ratio were increased by 65.9% and 70.3%, individually. With the maximum count 42% of the lesion ROI as the threshold, the lesions maximum size was of (5.65±2.77) cm after CTAC, which is coincidence with CT measurement results. Conclusion: Using X-ray attenuation correction helps to improve 99mTc-3PRGD2 quantitative analysis.
2013, Vol. 24 
