Abstract：Objective: To study the subregion of MR apparent diffusion coefficient maps(ADC maps) in piglet model with acute severe hypoxic ischemic encephalopathy(HIE), compared with clinical manifestation and pathology. Methods: Seven days old piglets(n=48) were divided into two groups randomly: group A (normal control group, n=5) and group B(HIE group, n=43, perform by bilateral common carotid artery occlusion and then inspirited 4% oxygen about 1 hour). According to the clinical manifestation of experimental animal, group B were divided into two subset: group B1(stable group, n=30) and group B2(aggravated group, n=13). ADC maps were got at the time point of 0, 1, 3, 6, 12, 18 and 24 hours after hypoxic ischemic, and 4 regions of interest(ROI Ⅰ~Ⅳ) were set from the minimum ADC values point to the consecutive normal ADC values area. The ADC values of 4 ROIs and the number of the focus were studied compared with clinical manifestation and pathology. Results: Multiple small patchy regions of hypointensity were found in the bilateral cerebrum by ADC maps, and most focuses were distributed in subcortical white matter, basal ganglia, thalami and periventricular white matter. The evolvement patterns of ADC values in 4 ROIs of two HIE groups were quite different, and markedly correlative with clinical manifestation and pathology. Conclusion: To analyze the evolvement patterns of ADC values in 4 ROIs of ADC maps could evaluate pathogenetic condition and prognosis of acute HIE.
2007, Vol. 18 
