Abstract：Objective: To compare the size of small airway evaluated by HRCT between young and middle-aged cigarette smokers without symptom and control group. Method: The outside diameter(DE) and inner diameter(DL) of grade 4~7 bronchi in apical segment of right upper lobe were measured in cigarette smokers without symptom and control group. The ratio of the thickness of the airway(T) and square root of surface area(√BSA), ratio of airway area and total area of the airway(WA%), and ratio of bronchi wall thickness and outer diameter(TDR) were calculated. Results: The T/√BSA in grade 4~7 bronchi in apical segment of right upper lobe was higher in cigarette smokers without symptom than that of control group, with statistical difference(P<0.05). WA% was lower, which was statistically significant(P<0.05). While TDR was slightly lower, without statistical difference(P>0.05). Conclusion: HRCT can be used to assess early damage in small airway of cigarette smokers.
许晓杰，卢辉群，叶向阳，叶 波，周 玮，蔡杭美. 青中年无症状吸烟者4~7级支气管损伤的HRCT研究[J]. 中国临床医学影像杂志, 2016, 27(12): 864-866.
XU Xiao-jie, LU Hui-qun, YE Xiang-yang, YE Bo, ZHOU Wei, CAI Hang-mei. Injury of grade 4~7 bronchi in the young and middle-aged cigarette smoking people without symptom: evaluation by HRCT. JOURNAL OF CHINA MEDICAL IMAGING, 2016, 27(12): 864-866.
[1]Hübner RH, Schwartz JD, De Bishnu P, et al. Coordinate control of expression of Nrf2-modulated genes in the human small airway epithelium is highly responsive to cigarette smoking[J]. Mol Med, 2009, 15(7): 203-219.
[2]Ahmad T, Sundar IK, Lerner CA, et al. Impaired mitophagy leads to cigarette smoke stress-induced cellular senescence: implications for chronic obstructive pulmonary disease[J]. FASEB, 2015, 29(7): 2912-2929.
[3]Liu L, Li G, Sun Y, et al. Airway wall thickness of allergic asthma caused by weed pollen or house dust mite assessed by computed tomography[J]. Respir Med, 2015, 109(3): 339-346.
[4]王娇莉，任振义，杨斌，等. 支气管哮喘和嗜酸粒细胞性支气管炎患者气道壁的CT比较研究[J]. 中国呼吸与危重监护杂志，2011，2（10）：126-129.
[5]辛小燕，贺文，谭春婷. HRCT定量评价哮喘和COPD患者气道壁厚度差异的研究[J]. 中国医学影像技术，2008，24（7）：1029-1032.
[6]Gupta S, Siddiqui S, Haldar P, et al. Quantitative analysis of high-resolution computed tomography scans in severe asthma subphenotypes[J]. Thorax, 2010, 65(9): 775-781.
[7]Auxiliadora M, Moreira C, Alves M, et al. Pulmonary changes on HRCT scans in nonsmoking females with COPD due to wood smoke exposure[J]. Bras Pneumol, 2013, 39(2): 155-163.
[8]Kim CH, Woo H, Hyun IG, et al. Pulmonary function assessment in the early phase of patients with smoke inhalation injury from fire[J]. Thorac Dis, 2014, 6(6): 617-624.
[9]Kim N, Seo JB, Song KS, et al. Semi-automatic measurement of the airway dimension by computed tomography using the full-width-half-maximum method: a study on the measurement accuracy according to the CT parameters and size of the airway[J]. Kor J Radiol, 2008, 9(3): 226-235.
[10]Khadadah M, Jayakrishnan B, Muquim A, et al. High resolution computed tomography in asthma[J]. Oman Med J, 2012, 27(2): 145-150.
[11]Stratelis G, Fransson SG. High prevalence of emphysema and its association with BMI: a study of smokers with normal spirometry[J]. Scand J Prim Health Care, 2008, 26(4): 241-247.
[12]Dijkstra AE, Postma DS, Hacken N, et al. Low-dose CT measurements of airway dimensions and emphysema associated with airflow limitation in heavy smokers: a cross sectional study[J]. Respir Res, 2013, 14(1): 11-12.
[13]Karimi R, Tornling G, Forsslund H, et al. Lung density on high resolution computer tomography(HRCT) reflects degree of inflammation in smokers[J]. Respir Res, 2014, 15(1): 23-28.
