Experimental study of 4D DCE MRI in identifying ischemic renal impairment and dysfunction in rats
YANG Chao-wu1, HE Guang-wu1, WANG Juan2
1.Department of Radiology, Baoshan Branch of Shanghai First People's Hospital, Shanghai 200940, China;
2.Shanghai Baoshan District Yanghang Community Healthcare Center, Shanghai 200940, China
Abstract：Objective: To investigate the value of four-dimensional dynamic contrast enhancement magnetic resonance imaging(4D DCE-MRI) in evaluating renal impairment and dysfunction in rats compared with SPECT renography and pathology. Materials and Methods: Twenty-four male SD rats were selected to establish the left renal artery stenosis model, and the rats underwent 99mTc-DTPA SPECT renal imaging and 4D DCE-MRI in 2, 3 and 4 weeks after operation, and the glomerular filtration rate(GFR) was measured by 99mTc-DTPA SPECT renal imaging. The Ktrans, Ve Kep, iAUC under ST-T curve were measured three times by Tissue 4D software of magnetic resonance workstation, and the mean value was obtained. The correlation between Ktrans, Ve, Kep, iAUC measured by 4D DCE-MRI and GFR obtained by SPECT renal imaging was analyzed. Paired-samples T test and non-parametric Spearman correlation analysis were used in statistical methods. Results: Renal cortical and medullary Ktrans, medullary Ve and Kep had a significant correlation with GFR(P<0.05). Cortex Ktrans(r=0.518), medulla Ktrans(r value was 0.548) had the highest correlation with GFR. The ST-T curve of renal cortex, medulla and pelvis could reflect the abnormal blood supply and excreting dysfunction, and iAUC value had a certain correlation with GFR (P<0.05, r value was 0.497). Conclusion: 4D DCE-MRI has great potential value in evaluating renal parenchymal injury and renal dysfunction. Ktrans value can quantitatively analyze the degree of renal injury. The ST-T curves of renal cortex, medulla and pelvis can also help to visualize the abnormal changes of renal blood flow and excretion. iAUC can quantitatively analyze the degree of renal injury to a certain extent.
杨朝武1，何光武1，王 娟2. 四维DCE MRI评估大鼠缺血性肾脏结构及功能损伤的实验研究[J]. 中国临床医学影像杂志, 2019, 30(9): 640-645.
YANG Chao-wu1, HE Guang-wu1, WANG Juan2. Experimental study of 4D DCE MRI in identifying ischemic renal impairment and dysfunction in rats. JOURNAL OF CHINA MEDICAL IMAGING, 2019, 30(9): 640-645.
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2019, Vol. 30 
