Abstract：Objective: The synthesis 18F-FLT with one pot method used 1-Butyl-3-methylimidazolium trifluoromethanesulfonate(BMI) ionic liquid(IL) as phase transfer catalysis(PTC). To develop the simple, quickly, stability synthesis 18F-FLT method for clinical application. Materials and Methods: To separate 18F ionic transferred from cyclotron first. We study 18F-FLT productivity with the different K2CO3 volume, heat temperature and precursor quantity used 3-N-tert-Butoxycarbonyl-[5’-O-(4, 4’-dimethoxytripphenylmethyl)-2’-deoxy-3’-O-(4-nitrobenzenesulfonyl)-b-D-threopentofuranosyl] thymine as precursor and BMI as PTC. Results: We can get the highest yield of 18F-FLT synthesis with 0.1ml 1M, 130℃ and 30mg precursor. Conclusions: BMI IL can be used PTC to synthesize 18F-FLT which has fast higher yield and high stability.
辛 军;李宏利;郭启勇;赵周社. 采用离子液体作为相转移催化剂一步法合成18F-FLT的方法研究[J]. , 2007, 18(5): 348-350.
XIN Jun;LI Hong-li;GUO Qi-yong;ZHAO Zhou-she. Synthetic methods research of 18F-FLT as phase transfer calalyst by ionic liquid with one pot methodology. , 2007, 18(5): 348-350.
2007, Vol. 18 
