Fractional amplitude of low-frequency fluctuation study of resting-state functional MRI in internet gaming addicts of adolescents
DU Gui-jin1, LI Xiao-dong1, ZHANG Quan2, YANG Yong-xin3, ZHAO Song-tao3, LI Fu-zhou1, ZHU Shi-cai1, SONG Zhen-wei1
1. Linyi People’s Hospital, Linyi Shandong 276003, China; 2. Department of Radiology, General Hospital of Tianjin Medical University, Tianjin 300052, China; 3. Linyi Mental Health Center, Linyi Shandong 276004, China
Abstract：Objective: To evaluate brain activity in resting-state in internet gaming addicts of adolescents with fractional amplitude of low-frequency fluctuation(fALFF). Methods: Seventeen internet gaming addicts of adolescents and nineteen healthy controls, well matched in age, gender, education and handedness, underwent functional MRI in resting-state, and the difference of fALFF between addicts and controls was analyzed with two-sample t test. Results: Comparing with the controls, bilateral dorsal lateral prefrontal cortex(DLPFC), right medial part of prefrontal cortex(MPFC), right anterior part of cingulate gyrus(ACC), bilateral posterior cingulated cortex(PCC), left limbic lobes, right hippocampus, and right temporal lobes showed increased activation, and decreased activation was found in right temporal lobes, bilateral occipital lobes, right thalamus, right splenium of corpus callosum and of bilateral cerebellum in the addiction group under resting state condition(P<0.05, uncorrected). Conclusion: The resting-state fMRI study suggests abnormal brain activity of internet gaming addicts of adolescents might exist in resting state, and fALFF might contribute to the understanding of internet gaming addicts of adolescents brain function in resting state.
2014, Vol. 25 
