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| A comparison of virtual touch tissue quantification and digital rectal examination for prostatic lesions |
| GONG Ji-jun, LIU Li, XUE Min, SHI Yu, WU Guo-ru, ZHANG Yan, TAO Ling-zhi |
| Peking University Shenzhen Hospital, Shenzhen Guangdong 518036, China |
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Abstract Objective: Virtual touch tissue quantification(VTTQ) is a new, promising technique for detecting the stiffness of tissues. The aim of this study is to compare the performance of VTTQ and digital rectal examination(DRE) in discrimination between prostate cancer(PCa) and benign prostatic hyperplasia(BPH). Methods: VTTQ was performed in 60 patients with suspected BPH and PCa before the prostate histopathologic examination. The shear wave velocity(SWV) at each nodular lesion was quantified by implementing an acoustic radiation force impulse(ARFI). The performance of VTTQ and DRE in discrimination between PCa and BPH was compared by the pathology. Results: The SWV values(m/s) were significantly greater in PCa and BPH than in normal prostate(2.97±0.42, 2.61±0.47 and 2.46±0.52). The area under the receiver operating characteristic curve(AUC) for VTTQ(SWV>2.87 m/s) to differentiate prostate nodules as benign hyperplasia or malignancy was 0.78, while it was 0.67 for DRE. The diagnostic sensitivity, specificity, PPV, NPV and accuracy were 80.0%, 66.7%, 74.3%, 72.0%, 79.2%, respectively for VTTQ(SWV>2.87 m/s), whereas they were 57.5%, 52.3%, 62.5%, 57.0%, 62.1% respectively for DRE. Conclusion: VTTQ can effectively detect the stiffness of prostate nodular lesions, which has a significantly higher performance than DRE in discrimination between PCa and BPH.
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Received: 06 May 2016
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