|
|
|
| Application value of color Doppler ultrasonography examination on early joint lesion in hemophilia patients |
| GAO Shu-xi, LI Jian-min, WANG Huan |
| Department of Ultrasound, Shengjing Hospital of China Medical University, Shenyang 110004, China |
|
|
|
|
Abstract Objective: To investigate the clinical values and manifestations of early joint lesion in patients with hemophilia by using the ultrasonographic. Methods: Forty-seven patients were diagnosed with moderate to severe hemophilia on the knee, elbow and ankle joints on color Doppler ultrasonography image. The joint ultrasound characteristics were scored with HEAD-US scoring system and graded according to level of the synoval blood flow. Results: Synovial hyperplasia was found in 21.7%(60/277) of the joints, cartilage destruction was showed in 9.4%(26/277) of the joints and bone destruction was displayed in 10.1%(28/277) of the joints. The correlation between HEAD-US score, synovial hyperplasia, synovial blood flow and the number of bleedings within half year and total number of bleeding is positive. Conclusion: Ultrasound can find many early joint lesions in hemophilia patient, it is hopeful to be a feasible and reliable tool to evaluate the early joint disease of hemophilia and guide individual treatment.
|
|
Received: 03 May 2017
|
|
|
|
|
|
[1]Srivastava A, Brewer AK, Mauser-Bunschoten EP, et al. 血友病处理指南中文版[M]. 李洪强，译. 世界血友病联盟出版，2008：4.
[2]Blobel CP, Haxaire C, Kalliolias GD, et al. Blood-induced arthropathy in hemophilia: mechanisms and heterogeneity[J]. Semin Thromb Hemost, 2015, 41(8): 832-827.
[3]Jelbert A, Vaidya S, Fotiadis N. Imaging and staging of haemophilic arthropathy[J]. Clin Radiol, 2009, 64(11): 1119-1128.
[4]Bhasin S, Cheung PP. The Role of Power Doppler Ultrasonography as Disease Activity Marker in Rheumatoid Arthritis[J]. Dis Markers, 2015, 2015: 325909.
[5]Plaza M, Nowakowska-Plaza A, Pracoń G， et al. Role of ultrasonography in the diagnosis of rheumatic diseases in light of ACR/EULAR guidelines[J]. J Ultrason, 2016, 16(64): 55-64.
[6]李军，丁小玲，吕冰梅，等. 血友病性膝关节病的超声特征[J]. 中华血液学杂志，2014，35（5）：434-437.
[7]张宁宁，吴润晖，彭芸. 高频超声评估儿童血友病性骨关节病的初步研究[J]. 中华超声影像学杂志，2014，23（8）：701-704.
[8]Martinoli C, Della Casa Alberighi O, Di Minno G, et al. Development and definition of a simplified scanning procedure and scoring method for Haemophilia Early Arthropathy Detection with Ultrasound (HEAD-US)[J]. Thromb Haemost, 2013, 109(6): 1170-1179.
[9]Hartung W, Kellner H, Strunk J, et al. Development and evaluation of a novel ultrasound score for large joints in rheumatoid arthritis One year of experience in daily clinical practice[J]. Arthritis Care Res(Hoboken), 2012, 64(5): 675-682.
[10]Foppen W, van der Schaaf IC, Fischer K, et al. Value of routine ultrasound in detecting early joint changes in children with haemophilia using the ‘Haemophilia Early Arthropathy Detection with UltraSound’ protocol[J]. Haemophilia, 2016, 22(1): 121-125.
[11]Ayral X, Pickering EH, Woodworth TG, et al. Synovitis: a potential predictive factor of structural progression of medial tibiofemoral knee osteoarthritis—results of a 1 year longitudinal arthroscopic study in 422 patients[J]. Osteoarthritis Cartilage, 2005, 13(5): 361-367.
[12]郭文娟，赵永强. 血友病关节病的发病机制及危险因素[J]. 血栓与止血学，2012，18（1）：42-44.
[13]杨仁池，王鸿利. 血友病[M]. 2版. 上海：上海科学技术出版社，2016：37-38.
[14]Rodríguez-Merchán EC. Effects of hemophilia on articulations of children and adults[J]. Clin Orthop Relat Res, 1996, (328): 7-13. |
|
|
|
