应用VBM-DARTEL方法研究颞叶癫痫患者脑灰质和白质及与执行功能的关系

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Abstract Objective: To measure the volumetric changes of grey and white matters in patients with temporal lobe epilepsy(TLE) using voxel-based morphometry-diffeomorphic anatomical registration through exponential lie algebra(VBM-DARTEL) and to study its relationship with the executive function. Methods: Sixteen left-sided temporal lobe epilepsy(lTLE) patients, 26 right-sided temporal lobe epilepsy(rTLE) patients and 38 healthy controls(HC) underwent routine MRI scanning and acquisition 3D fast gradient echo T1 weighted imaging. The VBM-DARTEL method was used to calculate grey matter and white matter volume values after segmentation, and the brain regions with statistical difference were obtained(P<0.001, uncorrected, K≥50), the attention network test was used to evaluate the executive function, and the relationship between the volume value of grey matter and white matter and executive function was studied. Results: TLE patients had diffuse cerebral atrophy, grey matter atrophy of brain regions was mainly in temporal lobe and frontal lobe. The white matter was mainly in temporal lobe and hippocampus, the right anterior lobe of grey matter in rTLE patients was less than that in lTLE patients, no grey and white matter volume increased, compared to HC, the TLE patients’ executive network efficiency values were significantly increased(P<0.05), and executive network efficiency values of the lTLE patients were significantly higher than that of the rTLE patients(P<0.05), and executive network efficiency values were negatively correlated with grey matter volumes in rTLE patients. Conclusion: There are changes in brain structure of the TLE patients. There were differences in the structure and function of patients with different origin lesions. In rTLE patients, the decrease in the volume of grey matters have led to a decline in executive function.

Key words： Epilepsy, temporal lobe Magnetic resonance imaging

Received: 17 July 2017

PACS:	Ｒ742.1
	Ｒ445.2

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	Articles by authors
	GUO Dan-ni
	GAO Yu-jun
	LI Ya-ping
	ZHENG Jin-ou

Cite this article:

GUO Dan-ni,GAO Yu-jun,LI Ya-ping, et al. A study of grey and white matters in temporal lobe epilepsy patients by using VBM-DARTEL and the correlation with executive function[J]. JOURNAL OF CHINA MEDICAL IMAGING, 2018, 29(4): 229-233.

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http://www.jccmi.com.cn/EN/ OR http://www.jccmi.com.cn/EN/Y2018/V29/I4/229

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