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| Value of quantitative parameters of three dimensional histogram by dynamic contrast enhanced MRI in differential diagnosis of the heterogeneity of hepatocellular carcinoma and hepatic metastases of colorectal adenocarcinoma |
| ZHU Lv-cong1, ZHAO Zhen-hua1, YANG Jian-feng1, HUANG Ya-nan1, WANG Ting1, #br#
ZHANG Ya-ping1, LU Zeng-xin1, YANG Li-ming1, SUN Jun-hui2 |
1. Department of Radiology, Shaoxing Hospital of Zhejiang University(Shaoxing People’s Hospital), Shaoxing Zhejiang 312000, China;
2. Hepatobiliary and Pancreatic Intervention Center, First Affiliated Hospital, School of Medicine, Zhejiang University, Hangzhou 310003, China |
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Abstract Objective: To investigate the value of quantitative parameters of three dimensional histogram by dynamic contrast enhanced MRI(DCE-MRI) in the differential diagnosis of the heterogeneity of hepatocellular carcinoma(HCC) and hepatic metastases of colorectal adenocarcinoma. Methods: A total of 59 cases pathologically confirmed as HCC or hepatic metastases who had routine abdominal MRI and DWI scans were retrospectively analyzed. There were 41 cases of HCC and 18 cases of hepatic metastases. Liver double blood supplement and dual-input extended Tofts model were used, and 3D ROIs of all lesions were delineated to get the perfusion parameters of DCE-MRI, including transfer constant(Ktrans), rate constant(Kep), extravascular extracellular volume fraction(Ve), blood plasma space volume fraction(Vp) and hepatic arterial perfusion index(HPI).Then the three dimensional histogram analysis of these parameters was performed to get the median, mean, skewness, kurtosis, energy, entropy, 10th percentile, 90th percentile. We used independent t test and Mann-Whitney U test to compare the differences of the parameters, and drew the ROC curves to evaluate the value of the parameters in the differential diagnosis of HCC and hepatic metastases. Results: There were significant differences between HCC and hepatic metastases in Histogram-based Ktrans, Kep(median, mean, 10th, 90th), Kep(energy, entropy), Ve(median, skewness, 10th, 90th), Vp(skewness, kurtosis, energy, entropy, 90th) and HPI(median, Mean, 90th)(P<0.05). There was no significant difference in the rest of the parameters(P>0.05).The Kep(90th) had the highest area under curve(AUC, 0.930). Conclusion: The quantitative parameters of three dimensional histogram of DCE-MRI can be used to identify the heterogeneity of HCC and hepatic metastases of colorectal adenocarcinoma. Among these parameters, the Kep(90th) has a high diagnostic efficiency.
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Received: 06 November 2018
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[1]Ippolito D, Colombo M, Trattenero C, et al. Diagnostic Value of Semiquantitative Analysis of Dynamic Susceptibility Contrast Magnetic Resonance Imaging with GD-EOB-DTPA in Focal Liver Lesions Characterization: A Feasibility Study[J]. Gastroenterol Res Pract, 2015, 2015: 630273.
[2]Chen BB, Shih TT. DCE-MRI in hepatocellular carcinoma-clinical and therapeutic image biomarker[J]. World J Gastroenterol, 2014, 20(12): 3125-3134.
[3]张晖，王勇，张海龙，等. MR灌注动力学模型的研究进展[J]. 中华放射学杂志，2014，48（8）：702-704.
[4]王君鑫，赵文露，杨毅，等. 动态增强MRI三维定量参数直方图诊断前列腺癌的价值[J]. 中华放射学杂志，2016，50（8）：609-614.
[5]章俞，赵振华，赵丽，等. Extended Tofts和Exchange模型的动态对比增强MRI参数鉴别诊断肝细胞癌和肝转移瘤的价值[J]. 中华放射学杂志，2015，49（9）：656-660.
[6]Ng F, Ganeshan B, Kozarski R, et al. Assessment of primary colorectal cancer heterogeneity by using whole-tumor texture analysis: contrast-enhanced CT texture as a biomarker of 5-year survival[J]. Radiology, 2013, 266(1): 177-184.
[7] Kekelidze M, D’Errico L, Pansini M, et al. Colorectal cancer: Current imaging methods and future perspectives for the diagnosis, staging and therapeutic response evaluation[J]. World J Gastroenterol, 2013, 19(46): 8502-8514.
[8]Zhiwei Li, Tao Ai, Yiqi Hu, et al. Application of whole-lesion histogram analysis of pharmacokinetic parameters in dynamic contrast-enhanced MRI of breast lesions with the CAIPIRINHA-Dixon-TWIST-VIBE technique[J]. J Magn Reson Imaging, 2018, 47(1): 91-96.
[9]Koo HR, Cho N, Song IC, et al. Correlation of perfusion parameters on dynamic contrast-enhanced MRI with prognostic factors and subtypes of breast cancers[J]. J Magn Reson Imaging, 2012, 36(1): 145-151.
[10]Just N. Improving tumour heterogeneity MRI assessment with histograms[J]. Br J Cancer, 2014, 111(12): 2205-2213. |
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