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| Feature analysis of high-frequence ultrasound and neural eletrophysiological examination in peripheral neuropathy caused by type 2 diabetes mellitus |
| MA Xi-shun, DU Li-zhen, LEI Ting-ting, HAN Tong-liang |
| Department of Ultrasond, Qingdao Municipal Hospital Affiliated Hospital of Qingdao University, Qingdao Shandong 266071, China |
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Abstract Objective: To summarize the high-frequence ultrasound features in peripheral neuropathy(DPN) patients of type 2 diabetes, and to analyze their correlation with neural eletrophysiological examination. Methods: According to neural eletrophysiological examination, forty patients with type 2 diabetes mellitus were divided into the non-DPN group(group A, 20 cases) and DPN group (group B, 20 cases), and 23 non-diabetic patients were enrolled as the control group(group C). The diameter(D1), anteroposterior diameter(D2) and cross-sectional area(CSA) were measured in seven points of median nerve. Then, the ultrasound imaging features were observed. Moreover, the correlation between ultrasound and neural eletrophysiological examination was analyzed. Results: Sixty-three participants(36 men, 27 women, average age (54.32±12.08) years old) were enrolled. ①Compared with group C, D1, D2 and CSA of group A and B were often increased with significant difference. Compared with group A, D1 and CSA of group B were often increased with significant difference.②On the basis of the receiver operating characteristic curve, the highest diagnosis value was at MN6 level, and the cutoff values of CSA were 9.61 mm2 and 10.65 mm2. ③Moreover, the disappearance of screen structure, hypoechoic, thickened epineurium and increased blood flow was shown, especially at the level of MN4, MN5, MN6. ④According to correlation analysis, CSA was positively correlated with distal motor latency and negatively correlated with motor conduction velocity, sensory conduction velocity and sensory nerve action potential amplitude. Conclusion: DPN represents with the increase of D1, D2 and CSA, the disappearance of screen structure, hypoechoic, thickened epineurium and increased blood flow. Moreover, there is some correlation between ultrasound and neural eletrophysiological examination. To some extent, high-frequence ultrasound could help diagnose DPN early.
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Received: 12 November 2018
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