血液透析对老年患者血脂代谢及颈动脉超声改变的影响

doi:DOI:10.12117/jccmi.2020.04.005

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Abstract Objective: To analyze the effect of hemodialysis on carotid ultrasound and lipid metabolism in elderly patients. Methods: One hundred and fifty elderly hemodialysis patients and 120 normal subjects were selected as the elderly hemodialysis group(age 60~83) and the control group(age 60~85). Cholestero(TC), triglyceride(TG), high-density lipoprotein(HDL-C), low-density lipoprotein(LDL-C), apolipoprotein A1(apoA1), apolipoprotein B(apoB) and fibrinogen(FIB) were measured. All subjects underwent bilateral carotid color Doppler Ultrasonic examination. Results: The levels of TC, TG, LDL-C and apoB in the elderly hemodialysis group were significantly higher than those in the control group(P<0.05). The FIB in the elderly hemodialysis group was significantly higher than that in the control group(P<0.01). There were significant differences in the carotid intima-media thickening, plaque detection rate and artery stenosis rate between the elderly hemodialysis group and the control group(P<0.01). Conclusion: Hemodialysis can affect the metabolism of blood lipid and the change of carotid ultrasound in elderly patients, mainly make the vascular endothelial dysfunction, accelerate the process of carotid atherosclerosis. Carotid ultrasound can reflect the degree of vascular disease in elderly hemodialysis patients, and provide some basis for treatment and prevention.

Key words： Renal dialysis Carotid arteries Metabolism Ultrasonography

Received: 21 January 2019

PACS:	Ｒ692.5
	Ｒ543.4
	Ｒ445.1

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	Articles by authors
	LI Xiang1
	YANG Qing2
	XU Yan1

Cite this article:

LI Xiang1,YANG Qing2,XU Yan1. Effect of hemodialysis on blood lipid metabolism and carotid ultrasound in elderly patients[J]. JOURNAL OF CHINA MEDICAL IMAGING, 2020, 31(4): 248-251.

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http://www.jccmi.com.cn/EN/DOI:10.12117/jccmi.2020.04.005 OR http://www.jccmi.com.cn/EN/Y2020/V31/I4/248

[1]Vanholder R, Van Laecke S, Glorieux G, et al. Deleting Death and Dialysis: Conservative Care of Cardio-Vascular Risk and Kidney Function Loss in Chronic Kidney Disease(CKD)[J]. Toxins(Basel), 2018, 10(6): E237. [2]Daiber A, Steven S, Weber A, et al. Targeting vascular(endothelial) dysfunction[J]. Br J Pharmacol, 2017, 174(12): 1591-1619. [3]Chirakarnjanakorn S, Navaneethan SD, Francis GS, et al. Cardiovascular impact in patients undergoing maintenance hemodialysis: Clinical management considerations[J]. Int J Cardiol, 2017, 232: 12-23. [4]丹海俊，王燕，沙海静，等. 射频数据处理技术早期评价高甘油三脂血症患者颈动脉内-中膜厚度和血管弹性[J]. 中国超声医学杂志，2011，27（11）：1001-1003. [5]Parekh RS, Meoni LA, Jaar BG, et al. Rationale and design for the Predictors of Arrhythmic and Cardiovascular Risk in End Stage Renal Disease(PACE) study[J]. BMC Nephrol, 2015, 16: 63. [6]Salk I, Yildiz G, Egilmez H, et al. Carotid artery Doppler ultrasonography in patients with chronic kidney disease[J]. Med Sci Monit, 2014, 20: 11-17. [7]Hou JS, Wang CH, Lai YH, et al. Negative Correlation of Serum Adiponectin Levels With Carotid-Femoral Pulse Wave Velocity in Patients Treated With Hemodialysis[J]. Biol Res Nurs, 2018, 20(4): 462-468. [8]Tsai CW, Huang HC, Chiang HY, et al. Longitudinal lipid trends and adverse outcomes in patients with CKD: a 13-year observational cohort study[J]. J Lipid Res, 2019, 60(3): 648-660. [9]Newby AC. Metalloproteinase expression in monocytes and macrophages and its relationship to atherosclerotic plaque instability[J]. Arterioscler Thromb Vasc Biol, 2008, 28(12): 2108-2114. [10]苏楠，黄品同，张盛敏，等. 颈动脉粥样硬化斑块的超声造影表现与微血管密度的相关性研究[J]. 中国超声医学杂志，2018，34（3）：204-206. [11]王杰超，王建华，张莉，等. 血管回声跟踪技术定量评价高血压病患者颈动脉弹性的临床研究[J]. 中华超声影像学杂志，2007，16（3）：222-224. [12]陈秀华，陆召麟，吴明晓，等. 老年糖尿病患者颈动脉病变与血脂关系的研究[J]. 中华老年医学杂志，2014，23（8）：528-530. [13]周涛，苗兴和，程志颖. 糖尿病患者颈动脉彩色多普勒超声检测与血脂的关系分析[J]. 内蒙古医学杂志，2007，39（8）：231-235. [14]石梅，王金刚，侯华，等. 维持性血液透析患者降脂治疗对颈动脉硬化斑块的干预性研究[J]. 海南医学，2014，15（8）：2193-2195. [15]Shakeri A, Abdi M, Khosroshahi HT, et al. Common carotid artery intima-media thickness and atherosclerotic plaques in carotid bulb in patients with chronic kidney disease on hemodialysis: a case-control study[J]. Pak J Biol Sci, 2011, 14(17): 844-848. [16]阚艳敏，马琳，吴秀萍，等. 血管回声跟踪技术对正常高值血压伴高脂血症患者颈动脉弹性的研究[J]. 中国临床医学影像杂志，2012，23（4）：233-235. [17]Janda K, Krzanowski M, Dumnicka P, et al. Transforming growth factor beta 1 as a risk factor for cardiovascular diseases in end-stage renal disease patients treated with peritoneal dialysis[J]. Clin Lab, 2014, 60(7): 1163-1168. [18]李丽娜，徐岩，李翔. 血液透析对肱动脉血管内皮功能影响的临床研究[J]. 中国中西医结合肾病杂志，2011，12（2）：141-143. [19]胡文莉，孙岩，郭辉，等. 维持性血液透析患者颈动脉钙化情况和血流参数的变化[J]. 中国医药，2018，13（11）：1716-1719. [20]王艳艳，卞维静，杨娇，等. 血液透析患者心脏瓣膜钙化与颈动脉粥样硬化的关系及影响因素[J]. 中国血液净化，2016，15（9）：478-482.