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| The application value of quantitative assessment of age-related reduction of carotid artery elasticity by
ultrafast pulse wave velocity and the effect of mean arterial pressure on it |
| GAO Hui, ZHU Zheng-qiu, DAI Ping, WANG Han, ZOU Chong, LUAN Yun, LIU Niu, HUANG Hui |
| Jiangsu Province Hospital of Chinese Medicine, Affiliated Hospital of
Nanjing University of Chinese Medicine, Nanjing 210029, China |
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Abstract Objective: To explore the application value of quantitative assessment of age-related reduction of carotid artery elasticity by ultrafast pulse wave velocity and the effect of mean arterial pressure on it. Methods: A total of 435 patients, 138 healthy adults and 297 patients with risk factors for atherosclerosis were enrolled, and divided into 5 groups according to age intervals(25~＜35, 35~＜45, 45~＜55, 55~＜65, ≥65 years old). Detailed clinical data were collected from all the enrolled subjects, and pulse wave velocity of beginning systole(PWV-BS) and pulse wave velocity of ending systole(PWV-ES) of bilateral carotid artery were measured by ufPWV technology. The correlations between PWV-BS, PWV-ES, MAP and age were analyzed. Then the differences of PWV-BS and PWV-ES among different age intervals were compared, and the possible influence of blood pressure on ufPWV detection was further analyzed according to the stratification of mean arterial pressure(MAP). Results: There were great significant correlations between age and PWV-BS(r=0.25, P<0.001), PWV-ES(r=0.615, P<0.001), MAP(r=0.25, P<0.001). Both PWV-BS and PWV-ES were increased with age(P<0.001). When divided by MAP categories, the PWV-ES of the high MAP subgroup(MAP≥100 mmHg) and the low MAP subgroup(MAP<100 mmHg) both increased with age. The PWV-ES of the high MAP subgroup were significantly higher than those of the low MAP subgroup at the age intervals of 25~＜35, 35~＜45, 45~＜55, 55~＜65 years old(all P<0.05), but there was no significant difference at the age interval of ≥65(P=0.126). Conclusions: Different mean arterial blood pressure has significant influence on the quantitative evaluation of age-related carotid arterial elastic degeneration by ufPWV, so the effect of different blood pressure and age on the measured value of carotid artery elasticity should be noted in the clinical application of this technology.
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Received: 29 May 2019
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