Abstract：Objective: To investigate the value of Lung RADS grading in the screening of lung cancer and the characteristics of malignant nodules, and to improve the diagnostic accuracy. Methods: The findings on baseline screening in 2 580 persons at high-risk for lung cancer were retrospectively analyzed. According to the Lung RADS grading standards, solid and part solid nodules ≥6 mm, ground-glass density nodules ≥20 mm served as a positive value for screening to observe lung cancer positive predictive rate of RADS 3-4 pulmonary nodules, and followed-up to analyze nodule in detail characteristics change. Results: Compared with the screening positive results of the international early lung cancer action program(I-ELCAP), baseline screening overall positive rate was decreased from 22.9%(591/2 580) to 13.8%(357/2 580), lung cancer-positive prediction rate was increased from 6.9%(41/591) to 11.5%(41/357). 8 cases of lung cancer were confirmed by surgery and pathology among 246 cases(Grade 3), 33 cases of lung cancer were diagnosed by pathology among 111 cases(Grade 4A+4B), 41 cases of lung cancer were diagnosed among 357 cases(Grade 3+4), and the number of lung cancer was the same as that of I-ELCAP. Conclusion: Lung RADS grading may be more reasonable to classify the results of lung cancer screening, and reduce the follow-up frequency of patients with low risk, improve the positive rate of lung cancer, combined with the characteristics changes of the nodules, the diagnostic accuracy of pulmonary nodules was greatly improved.
2015, Vol. 26 
