Abstract：Objective: To study the feature of spectroscopy and metabolism in chronic hepatitis B by in vivo31P MR spectroscopy, and investigate its relationship to the serum transaminase. Methods: Twenty healthy controls and 26 patients with etiologic-proven HBV-related liver were studied. Base on the status of hepatic function, patients were divided into mild, moderate, severe and normal liver function hepatitis. Hepatic MR scanning and 31P MR spectra were obtained using 1.5T spectroscopy system. To investigate the feature of the spectrum and metabolism in chronic hepatitis B, and the relationship to the serum transaminase. Results: The %PME and PME/PDE of control group are 9.32±2.74 and 0.31±0.06, the value in normal liver function hepatitis are 9.5±4.2 and 0.32±0.14, in mild group are 10.97±1 and 0.38±0.08, in moderate group are 12.59±3.18 and 0.45±0.13, in severe group are 15.49±4.7 and 0.53±0.14. There were insignificant differences between control group and hepatitis with normal liver function. There were significant differences between control group and severe, mild and severe in %PME. A monotonic increase in PME/PDE ratio with increasing severity of disease was statistically significant differences between the control and moderate, control and severe, mild and severe. The PME/PDE ratio correlated with the alanine aminotransferase(ALT), but not correlated with aspartate aminotransferase(AST). Conclusion: We can detect the status of hepatic metabolism and energy by 31P MRS noninvasively and directly, and is valuable to investigate the status of hepatic function in chronic hepatitis B.
2007, Vol. 18 
