JOURNAL OF CHINA MEDICAL IMAGING

Office Online

Journal Online

Advanced Search

期刊信息

创刊日期：1990年
主管单位：中国人民共和国卫生部
主办单位：中国医学影像技术研究会
　　　　　中国医科大学
承办单位：中国医科大学附属盛京医院
　　　　　辽宁省医学影像学会
编辑出版：《中国临床医学影像杂志》
　　　　　编辑部
刊　　期：月刊

2016 Vol. 27, No. 12 Published: 2016-12-20

	837	Research on correlation between aquaporin magnetic resonance molecular imaging and AQP4 expression
		CHEN Qiu-yan, WU Fu-lin, PENG Xiao-lan, LI Chun-li, JIANG Min, CHEN Ting-ting, WEI Ding-tai
		Objective: To explore the correlation between aquaporin magnetic resonance molecular imaging(AQP MRI) and the expression of AQP4. Methods: Ten adult SD male rats were subjected to either predisposing(LRP) or sham surgery and then subsequently underwent right middle cerebral artery occlusion(MCAo) for one hour. AQP MRI was executed 48 h after reperfusion. And the AQP4 expression was detected by Western blot. Results: The success rate of modeling was 60%, meaning there were only 6 rats living up to the criteria of modeling. AQP MRI showed AQP ADC values of the affected side of rats No.1~5 were lower than those of the uninjured side, but the AQP ADC values in the affected side of rat No.6 was much higher than that of the uninjured side. Western blot results showed that the AQP4 expression in the affected side of No.1~6 rats was higher than that of the uninjured side. Correlation analysis showed that the AQP ADC values were negatively correlated to the level of AQP4 protein expression when excluding rat No.6. Conclusion: AQP MRI can display the expression quantity as well as the distribution of AQP4 in vivo, and it has great value in clinical application.
		2016 Vol. 27 (12): 837-841 [Abstract] ( 887 ) HTML (1 KB) PDF (0 KB) ( 179 )

	842	Ultrasonic diagnosis of premature infant with periventricular leukomalacia by Snake model software
		HE Xue-hua, GUAN Bu-yun, ZHU Li-ling
		Objective: To explore the value of quantified analysis of periventricular leukomalacia(PVL) using color Doppler ultrasound and Snake model medical image analysis software. Methods: The cranial ultrasound examination was performed in 120 premature infants with PVL within 7 days after birth. And 80 newborns were taken as control group. According to the gray anatomic distribution of ultrasound images, using the “manual analysis” to fix edge, five regions-of-interest(ROIs) were identified: basal ganglia, area around the anterior horn of lateral ventricle, area around cornu posterious ventriculi lateralis, choroid plexus and cerebellar vermis. Two consecutive images from each ROI were digitally stored. For off-line analysis, the ROI corresponding to each structure was delineated and the average gray value was calculated. Reproducibility of the experimental data(image analysis software variation, EV) and reproducibility(variation measurer, AV) were analyzed, with 95% confidence intervals to reflect its variability for 120 cases of premature infants with PVL. Results: The average gray values of basal ganglia, area around the anterior horn of lateral ventricle, area around cornu posterious ventriculi lateralis in premature infants with PVL were 130.64±4.12, 131.35±3.02 and 133.46±2.94, respectively, higher than those in control group(92.51±6.89, 81.64±2.78 and 85.75±3.65)(μ=44.49, 119.78, 97.57, P<0.01). The average gray values in choroid plexus and cerebellar vermis of PVL premature infants were 132.90±4.88 and 132.25±2.56, respectively, with no significant difference with control group(131.98±5.82, 131.43±4.47). The repeatability EV was 2.70%, reproducibility AV was 0.56%, and the repeatability and reproducibility(R&R) was 2.70% for premature infants with PVL. Conclusion: Quantitative analysis of ultrasonographic gray value of premature infants with PVL is characteristic by Snake model medical image analysis software, which can provide important information in the early diagnosis and in evaluating the prognosis of this disease.
		2016 Vol. 27 (12): 842-846 [Abstract] ( 969 ) HTML (1 KB) PDF (0 KB) ( 428 )

	846	Ultrasonography features of hepatobiliary cystadenoma: report of one case
		HE Ming-feng, TANG Shao-shan

		2016 Vol. 27 (12): 846-846 [Abstract] ( 626 ) HTML (1 KB) PDF (0 KB) ( 261 )

	847	Three-dimensional ultrasound with Xplane imaging in measuring the corpus callosum, cavity of septum pellucidum and cerebellomedullary cistern of the newborns
		QIAN Xiao-qin, ZHANG Jin, ZHANG Dong-mei
		Objective: To discuss the advantage of the three-dimensional ultrasound with Xplane imaging in measuring corpus callosum, cavity of septum pellucidum and cerebellomedullary cistern of the newborns. Methods: Scanning through the fontanelle window, ordinary two-dimensional ultrasound and three-dimensional ultrasound with xplane imaging were used to measure the size of the neonatal corpus callosum and the septum pellucidum cavity. Scanning through the temporal window, three-dimensional ultrasound with Xplane imaging was used to measure the size of the cerebellomedullary cistern. Results: ①Some cavity of septum pellucidum disappeared in full-term babies but all existed in premature babies, and the volume of cavity of septum pellucidum in premature babies was greater than that of full-term babies. ②There was no difference in the reference value of the corpus callosum beween the common two-dimensional ultrasound and the three-dimensional ultrasound with Xplane imaging, but three-dimensional ultrasound with xplane imaging obviously saved time. ③The anteroposterior diameter of the newborn cerebellomedullary cistern had no correlation with the volume. Conclusion: Three-dimensional ultrasound with Xplane imaging is convenient, fast and accurate in measuring the size of the corpus callosum, cavity of septum pellucidum and cerebellomedullary cistern.
		2016 Vol. 27 (12): 847-879 [Abstract] ( 807 ) HTML (1 KB) PDF (0 KB) ( 231 )

	850	The role of high resolution diffusion-weighted imaging and dynamic contrast-enhanced MRI in the evaluation of sinonasal rhahdomyosarcoma
		HUANG Hong-yan1, HUANG Wen-hu2, SHU Jin-er1, WANG Feng2
		Objective: To identify MR imaging features of sinonasal RMS, including high resolution diffusion weighted imaging(DWI) and dynamic contrast-enhanced(DCE) MRI. Materials and Methods: MRI and clinical data of 15 patients were analyzed retrospectively． Imaging features of conventional MR(non-enhanced and dynamic contrast-enhanced), the ADC values and DCE-MRI parameters(n=8) were analyzed. The semiquantitative parameters included Tpeak, ERmax, Slopemax and WR. Results: In the 15 cases of RMS, 12 were unilateral while the other 3 were bilateral, including 10 in the ethmoid sinus, 3 in the maxillary sinus, and 2 in the multi-paranasal sinus． The lesions were invasive, destructive or expansive. Compared with gray matter, 10 of the tumors showed hypointensity and 5 showed isointensity on T1WI. And 15 demonstrated hyperintensity on T2WI． There were multiple linear high signals on T1WI and high or low signal on T2WI within the mass in 8 of the 15 tumors. Evaluated with gadolinium-enhanced imaging, 3 patients showed clustered enhancement while 5 patients showed ring or linear enhancement. The mean ADC value was (0.59±0.08)×10-3 mm2/s. The time-intensity curve(TIC) of DCE-MRI showed rapid enhancement and slow wash out in 6 cases, rapid enhancement and rapid wash out in 2 cases. Tpeak was (69.1±13.3), and WR was (2.2±0.5)%. Conclusions: Combined with conventional imaging, high resolution diffusion-weighted imaging and dynamic contrast-enhanced MRI have the potential to improve the diagnostic accuracy of sinonasal RMS.
		2016 Vol. 27 (12): 850-854 [Abstract] ( 812 ) HTML (1 KB) PDF (0 KB) ( 190 )

	855	Imaging findings of malignant tumors originated from frontal sinuses
		PAN Yu-cheng, HUANG Wen-hu
		Objective: To explore the CT and MRI findings of the primary malignant tumors of the frontal sinus, in order to improve the clinic diagnosis of these diseases. Methods: The imaging data of 14 patients with pathologically proved malignant tumors were analyzed retrospectively, including 5 squamous carcinomas(one of which cancerated from inverted papilloma), 3 plasmocytomas, 2 melanomas, 1 rhabdomyosarcoma, 1 small cell carcinoma, 1 osteosarcoma and 1 mesenchymal sarcoma. Eight patients underwent plain CT, 6 patients underwent enhanced CT scan, and 13 patients underwent MRI examinations. Results: Eleven lesions originated from the left frontal sinus, 2 lesions from the right, while one from bilateral sinuses. The lesions invaded orbit walls in 14 cases, ethmoid sinuses in 10 cases, forehead in 7 cases, anterior cranial fossa in 10 cases and contralateral frontal sinus in 3 cases. One lesion was a regular nodule, while the other 13 lesions were irregular or diffused. On plain CT of 8 cases, tumors showed isointensity. After contrast enhancement, four masses were heterogeneously enhanced and two were homogenously enhanced. The tumors eroded the anterior walls of frontal sinus in 7 cases, the posterior walls in 12 cases and inferior walls in 14 cases. On T2WI of MRI, 10 masses showed isointense or slightly hyperintense signal, 2 masses showed mixed isointense and hyperintense signal, 1 mass showed slightly hypointense signal. After contrast enhancement, 10 lesions showed heterogeneous enhancement on T1WI images, three plasmocytomas showed homogenous enhancement. Four masses showed limited diffusion on DWI, and one showed slightly limited diffusion. Conclusion: The most common malignant tumors that originate from frontal sinuses are squamous carcinoma, plasmocytoma and melanoma. The posterior and inferior walls of the frontal sinuses are eroded in most cases. Most lesions invade to the outside of the sinuses, including orbits, ethmoid sinuses and anterior cranal fossae. The masses show limited diffusion on DWI. Plasmocytoma and melanoma have some characteristic MR signals. Combining CT and MRI images is helpful to confirm the characters and ranges of the lesions.
		2016 Vol. 27 (12): 855-858 [Abstract] ( 982 ) HTML (1 KB) PDF (0 KB) ( 242 )

	859	Comparison of strain and shear-wave elastography for predicting the pathological response after breast cancer neoadjuvant chemotherapy
		MA Yan, ZANG Li, LI Jing, REN Wei-dong, DENG Li-jun
		Objective: To evaluate and compare the diagnostic performances of strain elastography(SE) and shear-wave elastography(SWE) for predicting the pathological response to breast cancer neoadjuvant chemotherapy(NACT). Methods: The study included 56 eligible cases with breast cancer. The stiffness of breast tumor was assessed by SWE and SE respectively before biopsy. Immunohistochemical analysis of biopsy and pathologic response after NACT were recorded. Logistic regression analysis was performed to explicit the independent factors of pathological complete response(pCR) of NACT. The receiver operating characteristics(ROC) curve, the area under the ROC curve(AUC) and the overall diagnostic efficacy were calculated. Z test was used to compare the differences among AUCs. Results: Postoperative findings confirmed 14 patients with pCR according to the Miller and Payne classification. The high elasticity score in SE and SWE mean stiffness were independent factors. Diagnostic test suggested SE strain ratio had the best overall predictive performance, with the AUC of 0.92±0.04(SE). And the AUC of SWE mean stiffness was 0.81±0.06(SE). However, the difference of AUC between SE strain ratio and SWE mean stiffness was not statistical(P=0.12). Conclusion: Ultrasonic elastography can predict pCR with good performance, which may improve the clinical value of NACT.
		2016 Vol. 27 (12): 859-863 [Abstract] ( 699 ) HTML (1 KB) PDF (0 KB) ( 151 )

	864	Injury of grade 4~7 bronchi in the young and middle-aged cigarette smoking people without symptom: evaluation by HRCT
		XU Xiao-jie, LU Hui-qun, YE Xiang-yang, YE Bo, ZHOU Wei, CAI Hang-mei
		Objective:　To compare the size of small airway evaluated by HRCT between young and middle-aged cigarette smokers without symptom and control group. Method: The outside diameter(DE) and inner diameter(DL) of grade 4~7 bronchi in apical segment of right upper lobe were measured in cigarette smokers without symptom and control group. The ratio of the thickness of the airway(T) and square root of surface area(√BSA), ratio of airway area and total area of the airway(WA%), and ratio of bronchi wall thickness and outer diameter(TDR) were calculated. Results: The T/√BSA in grade 4~7 bronchi in apical segment of right upper lobe was higher in cigarette smokers without symptom than that of control group, with statistical difference(P<0.05). WA% was lower, which was statistically significant(P<0.05). While TDR was slightly lower, without statistical difference(P>0.05). Conclusion: HRCT can be used to assess early damage in small airway of cigarette smokers.
		2016 Vol. 27 (12): 864-866 [Abstract] ( 693 ) HTML (1 KB) PDF (0 KB) ( 154 )

	867	A study of iterative model reconstruction technology in a cardiac coronary calcium anthropomorphic phantom
		TAN Jing, HOU Yang, GUO Wen-li, GAO Si-zhe
		Objective: To determine whether or not IMR with lower tube current could replace FBP with routine tube current, and to find the lowest possible tube current for coronary calcium scanning while maintaining accurate Agatston score, volumn score and mass score using a cadiac phantom. Meterials and Methods: An anthropomorphic thoracic and heart phantom containing 9 calcium-insert columns was used to measure the sum of the Agatston score, volumn score, mass score of the 9 columns, Agatston score of different diameter columns and different density columns. And then these measurements among different current and algorithm groups were compared. Using the measurements of 120 kV, 80 mAs with traditional FBP as gold standard(Group A), the measurements with tube voltage 120 kV, and lower tube current of 50 mAs, 40 mAs, 30 mAs and 20 mAs with IMR algorithm were kept as group B, C, D and E, respectively. Then each measurement was compared with gold standard, with P<0.05 as statistical significance. Result: There was no significant difference between each lower current group and group A. For noise, Group E was significantly higher than Group A(16.5±2.6 vs 8.77±1.55, P=0.005). There was no significant difference between group A and group B~D. The radiation dose of group D was 62.41% lower than that of group A((2.53±0.06) mGy vs (6.73±0.23) mGy). Conclusion: Technology IMR with lower tube current could replace FBP with 80 mAs. The optimal low dose group is group D(IMR with 120 kV, 30 mAs). The scanning dose of group D is 62.41% lower than group A.
		2016 Vol. 27 (12): 867-870 [Abstract] ( 707 ) HTML (1 KB) PDF (0 KB) ( 182 )

	871	Related factors for coronary artery damage of level Ⅱ, Ⅲ and Ⅳ in Kawasaki disease evaluated by echocardiography
		WANG Jing, ZHANG Chun-xia, XUE Mei, ZHANG Dan, HU Yan-hua, ZHANG Xiao-shan
		Objective: To analyze the related factors for coronary artery lesions(CAL) of level Ⅱ, Ⅲ and Ⅳ in Kawasaki disease(KD) diagnosed by echocardiography. Methods: We collected 416 children with KD as the research object in the past five years. We found 179 cases of level Ⅱ, Ⅲ and Ⅳ damage by echocardiography, defined as the case group, and 237 cases without damage, defined as the control group. We collected 44 clinical items such as age, gender and platelet count, which may be the related factors for artery damage of level Ⅱ, Ⅲ and Ⅳ in two groups. Data were analyzed by single factor analysis and multivariable logistic regression. Results: Increase of thermal process by 1 day, increase of platelet by 1×109 L-1, increase of blood sedimentation by 1 mm/h, increase of c-reactive protein by 1 μg/L and increase of N terminal brain natriuretic peptide precursor by 1 ng/L increased the risk of level Ⅱ, Ⅲ and Ⅳ damage by 1.254, 2.813, 1.073, 3.845 and 1.083 times, respectively, compared with the control(OR>1, the 95% confidence interval did not contain 1, P<0.05), and accelerated the course of the disease. The risk of level Ⅱ, Ⅲ and Ⅳ damage(OR>1, the 95% confidence interval did not contain 1, P<0.05) was 12.276 times higher in male than female, and also promoted the disease. IVIG and its initial time of 5~<10 days decreased the risk of level Ⅱ, Ⅲ and Ⅳ damage by 0.412 and 0.115 times, respectively, compared with those who were not given IVIG or with initial time <5 days or ≥10 days, (OR<1, the 95% confidence interval did not contain 1, P<0.05). Conclusion: Increasing of thermal process, platelet, blood sedimentation, C-reactive protein, N terminal brain natriuretic peptide precursor and male are risk factors for level Ⅱ, Ⅲ and Ⅳ damage. And IVIG with initial time of 5~9 days are its protective factors.
		2016 Vol. 27 (12): 871-874 [Abstract] ( 662 ) HTML (1 KB) PDF (0 KB) ( 131 )

	875	Liver-specific contrast agent Gd-EOB-DTPA enhanced MRI in the diagnosis of hepatocellular carcinoma: a Meta analysis
		SHI Hua-liang, MAO Ming-wei, LIANG Chang-yu
		Objective: To systematically assess the diagnostic performance of Gd-EOB-DTPA enhanced MRI for hepatocellular carcinoma(HCC) using a Meta analysis. Methods: The literatures about the Gd-EOB-DTPA enhanced MRI in the diagnosis of HCC taking the pathology or comprehensive results of clinic data, laboraotory examination, imageological examination and follow-up as a gold standard were got by researching the library database of Pubmed, Ovid, EBSCO, Cochrane library, Wanfang database, Weipu database and CNKI. The criteria were established based on validity criteria for diagnostic research published by the cochrane methods. The methodological quality of the included literatures was assessed and data were extracted. Statistical analysis was performed by using the Meta Disc 1.4 software. Heterogeneity of the included literatures was tested, which was used to select proper effect model to calculate the sensitivity, specificity, positive likelihood ratio(PLR), negative likelihood ratio(NLR) and diagnostic odds ratio(DOR). Then, the summary receiver operating characteristic curve(SROC) was got, and the area under curve(AUC) was calculated. Sensitivity analysis was carried on. Results: Totally 20 studies met the inclusion criteria. No significant threshold effect but heterogeneity was found in these studies. Using random effect model for meta-analysis, the sensitivity, specificity, positive likelihood ratio(PLR), negative likelihood ratio(NLR), diagnostic odds ratio(DOR) and their 95%CI were 0.87(95%CI 0.85~0.89), 0.94(95%CI 0.92~0.95), 10.69(95%CI 5.81~19.67), 0.11(95%CI 0.07~0.19) and 111.77(95%CI 53.71~232.60), respectively. AUC was 0.965 and Q index was 0.911. The sensitivity analysis demonstrated that the stability of included literatures was good. Conclusion: Liver-special contrast agent Gd-EOB-DTPA enhanced MRI can be regarded as an effective and feasible method for diagnosis of HCC, with higher sensitivity and specificity, providing important basis for clinic therapy.
		2016 Vol. 27 (12): 875-880 [Abstract] ( 872 ) HTML (1 KB) PDF (0 KB) ( 405 )

	881	A study of primovist in distinguishing transient hepatic parenchymal enhancement from small hepatocellular carcinoma and a comparison with non-specific contrast agent
		WANG Ai-bo1, LUO Jia-wen1, BIAN Jie1, LIU Jun2, CHEN Hong-hai1, ZHAI Fang-bing1, LIU Ya-jie1, YU Chuan-wen1, ZHANG Xi-you1
		Objective: To compare the ability of hepatocyte specific contrast agent Gd-EOB-DTPA with non-specific extracellular contrast agent Gd-DTPA in differential diagnosis of transient hepatic parenchymal enhancement(THPE) and small hepatocelluar carcinoma(small HCC). And to analyze the lesion shape, signal intensity, and enhancement pattern with two agents. Methods: Two radiologists analyzed the imaging characteristics of 58 focal liver lesions(FLL) from 46 patients with cirrhosis. The analysis focused on morphology, signal intensity and the patterns of enhancement in different phases with Gd-DTPA and Gd-EOB-DTPA respectively, and then the property of each focal liver lesion was inferred and compared with the final results. A retrospective analysis about the ability of two contrast mediums in detection and differential diagnosis of THPE and small HCC was performed with pathologic findings, angiography or follow-up over 6 months as reference and gold standard. The Chi-square test was used for comparisons of shape, location, signal intensity and pattern of enhancement between THPE and small HCC, comparison of enhancement pattern of THPE with the two MRI contrast agents, and comparison of enhancement pattern of small HCC with the two MRI contrast agents. Sensitivities, specificities and AUCs(area under curve) of ROCs of the two agents were figured out in the groups of total 58 FLL, 36 nodular FLL and 23 FLL whose maximum diameter＜1 cm, respectively, and thus calculating their diagnostic performance. Significance was set at P＜0.05. Among 39 THPEs, there were 33 cases confirmed by 6 months’ following up, and others were confirmed by angiography. Among 19 small HCCs, 10 cases were confirmed by postoperative pathology, 1 case was identified by percutaneous biopsy and angiography, and other 8 cases were confirmed by combining gangiography and AFP. Results: In different groups, the sensitivity, specificity and the AUC of Gd-EOB-DTPA were all higher than those of Gd-DTPA. Significant differences in shape, location, signal intensity and patterns of enhancement were observed between THPE and small HCC(P＜0.05). The patterns of enhancement of THPE with two agents showed no difference(P＞0.05), and the patterns of enhancement of small HCC with two agents showed no difference too. Conclusion: ①In magnetic resonance imaging(MRI), there are significant differences in shape, signal intensity, location and patterns of enhancement between THPE and small HCC, while the two MRI contrast agents show no statistical difference in the enhancement pattern of all focal liver lesions. ②Gd-EOB-DTPA has more advantages in distinguishing THPE from small HCC so it has a higher diagnostic performance than traditional contrast agent.
		2016 Vol. 27 (12): 881-887 [Abstract] ( 755 ) HTML (1 KB) PDF (0 KB) ( 176 )

	888	CT diagnosis of gastric glomus
		HUA Jian-jun, SHU Jin-er, YING Ming-liang, LU Jun
		Objective: To access the accuracy of CT in the diagnosis of gastric glomus and to discuss its value by reviewing the literature. Methods: A retrospective analysis of the CT characteristics of gastric glomus(such as tumor size, CT value, enhancement mode, feeding artery and draining vein, and so on) was done. The study included 5 cases of gastric glomus confirmed by surgery and pathology(3 females and 2 males, age range 49~72 years old, average age was 61 years old). Dynamic enhanced CT scanning and MPR was used. Results: All the lesions located in the gastric antrum(5 cases), with the diameter ranging from 1.8 to 3.2 cm, and the average size was 2.5 cm. The density of the lesions was uniform or not, without hemorrhage, necrosis or cystic changes. The enhancement of the tumors in arterial phase was obviously homogeneous or not, and they were homogeneously enhanced in portal vein phase, similar with the enhancement of the abdominal aorta. Also, feeding artery and draining vein were found in tumors. Conclusions: Although the gastric glomus tumor is relatively rare, it has certain imaging characteristics of vascular disease, with feeding arteries and companying veins. Dynamic enhanced CT has a high value in the diagnosis of the disease.
		2016 Vol. 27 (12): 888-891 [Abstract] ( 745 ) HTML (1 KB) PDF (0 KB) ( 211 )

	892	Evaluation of fallopian tube patency with transvaginal real-time three-dimensional hysterosalpingo contrast sonography
		ZHANG Shan, TIAN Li, BI Bei-lei, ZHANG Xiao-ying, CHEN Rong-jie, AN Chao, GUO Li
		Objective: To explore the clinical value of transvaginal real-time three-dimensional hysterosalpingo contrast sonography(RT-3D-HyCoSy) in the assessment of tubal patency. Methods: Imaging data of 62 patients with infertility examined by transvaginal RT-3D-HyCoSy was analyzed retrospectively, in which 25 cases were compared with laparoscopic hydrotubation. Results: One hundred and twenty one fallopian tubes were showed by RT-3D-HyCoSy in the 62 patients(3 patients had unilateral tube), among which 54 tubes were diagnosed to be patency, 41 incompletely occluded, and 26 occluded. RT-3D-HyCoSy was compared with laparoscopic hydrotubation in 25 cases, with the total coincidence rate of 86.00%(43/50) and consistency checking Kappa value of 0.702(P>0.05), showing high consistency for the two methods. Conclusion: RT-3D-HyCoSy could dynamically display the morphological character of fallopian tube real-time. RT-3D-HyCoSy is an accurate and effective approach to assess fallopian tube patency.
		2016 Vol. 27 (12): 892-895 [Abstract] ( 655 ) HTML (1 KB) PDF (0 KB) ( 195 )

	896	The effects of NF-κB antisense RNA gene on the levels of serum TNF-α and IL-1β in rheumatoid arthritis rats by ultrasound-mediated microbubble destruction
		LIU Jie, JING Xiang-xiang, YANG Bing-ang, FU Shao-qing, WANG Dong-lin, WU Tang-na
		Objective: To investigate the effect of NF-κB antisense RNA gene delivery mediated by ultrasound-mediated microbubble destruction on serum levels of TNF-α, IL-1β in rheumatoid arthritis(RA) rats and its feasibility for RA therapy. Methods: The layer-by-layer assembly technique was applied to attach multiple layers of gene and polyllysine onto prepared lipid-coated microbubbles(PLL+DNA+PLL Apply+DNA)． Sixty rats were divided into six groups(10 rats with 20 knees in each group). Group A: normal control group; group B: blank control group of RA rats; group C: NF-κB antisense RNA gene plasmid group; group D: ultrasound+NF-κB antisense RNA gene plasmid group; group E: microbubbles+NF-κB antisense RNA gene plasmid group; group F: ultrasound+microbubbles+NF-κB antisense RNA gene plasmid group. The serum levels of TNF-α, IL-1β in RA rats were detected with ELISA. Results: The levels of serum TNF-α and IL-1β were obviously higher than normal control group. Those of group C to F were notably lower than that of the RA control group(P＜0.05, P＜0.01). There was no statistical difference in the levels of serum TNF-α and IL-1β among group C, D and E. But there was statistics difference between group F and group C to E(P＞0.05). Conclusion: NF-κB antisense RNA gene transfection efficiency on RA rat’s joints synovial tissues can be enhanced by ultrasound-mediated microbubble destruction, which can down-regulate the levels of serum TNF-α and IL-1β, and enhance the therapeutic effect of RA.
		2016 Vol. 27 (12): 896-898 [Abstract] ( 912 ) HTML (1 KB) PDF (0 KB) ( 240 )

	899	Interventional therapy for delayed post-pancreaticoduodenectomy hemorrhage
		WANG Chuan-zhuo, LIU Zhao-yu
		Objective: To discuss the safety and efficacy of interventional therapy for delayed post-pancreaticoduodenectomy hemorrhage． Methods: Twenty-four patients undergoing interventional radiology treatments for delayed post-pancreaticoduodenecomy hemorrhage from July 2010 to June 2015 were included in the study. Clinical and imaging data were studied. Angiography findings, efficacy of embolization, and related complications were analyzed. The patients consisted of 16 males and 8 females with an age range of 37~74 years old. There were 14 patients of abdominal hemorrhage, 7 patients of gastrointestinal hemorrhage, 2 patients of abdominal and gastrointestinal hemorrhage, and 1 patient of hemorrhagic shock. Results: In the 24 patients, 22 patients(91.67%) had positive results of angiography. In the 22 patients, 12 patients showed pseudo-aneurysm, 7 patients showed pseudo-aneurysm and contrast media extravasation, 3 patients showed unsmooth arterial intima. Hemorrhage ceased in 19 patients(79.2%, 19/24) after interventional therapy. Two patients died of hemorrhagic shock. Four patients died of complications such as pancreatic fistula, infection shock and multi-organ failure within 1 month after the interventional therapy. Six patients died of tumor deterioration within 3~16 months. The rest 12 patients did not develop massive hemorrhage within 3~24 months. Four patients showed transient liver damage. Three patients with spleen arterial embolism and 2 patients with hepatic artery embolism showed limited extent of infarction. None of the patients showed severe complications such as intestinal necrosis or pancreatic necrosis. Conclusion: The interventional therapy is a safe and effective technique, and should be the first-line diagnosis and treatment choice for patients with post-pancreaticoduodenectomy hemorrhage．
		2016 Vol. 27 (12): 899-903 [Abstract] ( 952 ) HTML (1 KB) PDF (0 KB) ( 390 )

	904	Advances in imaging evaluation of neoadjuvant chemotherapy efficacy of triple negative breast cancer
		ZHU Can, SHEN Yan-yan
		Triple negative breast cancer(TNBC) is highly invasive. It is not sensitive to endocrine therapy, but has a good response to neoadjuvant chemotherapy. So NAC has become an important part of the comprehensive treatment of TNBC. The imaging evaluation of neoadjuvant chemotherapy is very important for early clinical treatment options, including mammography, ultrasound, MRI, PET-CT, etc. This article will provide an overview of these techniques used to evaluate the efficacy of neoadjuvant chemotherapy for TNBC.
		2016 Vol. 27 (12): 904-906 [Abstract] ( 908 ) HTML (1 KB) PDF (0 KB) ( 257 )

	907	CTA diagnosis of type Ⅱ persistent proatlantal intersegmental artery: report of one case
		FANG Rui, LIANG Yi, LI Zhen, DU Bo-lin

		2016 Vol. 27 (12): 907-908 [Abstract] ( 1137 ) HTML (1 KB) PDF (0 KB) ( 213 )

	908	Anomalous systemic arterial supply to the basal segments of the lower lobe of left lung: report of one case and literature review
		FANG Qiang1, CAO Xin2, ZHENG Ying-xin2, SHI Hao2

		2016 Vol. 27 (12): 908-909 [Abstract] ( 818 ) HTML (1 KB) PDF (0 KB) ( 213 )

	910	MR imaging of hyaline vascular type of Castleman’s disease confined to the subcapsule of kidney: report of one case#br#
		YU Jin-chao, WANG Li-ming, LI Zhen-zhi

		2016 Vol. 27 (12): 910-911 [Abstract] ( 988 ) HTML (1 KB) PDF (0 KB) ( 392 )

	911	Neuroendocrine carcinoma of the cervix: report of one case
		ZHU Da-lin, FENG Fan

		2016 Vol. 27 (12): 911-912 [Abstract] ( 861 ) HTML (1 KB) PDF (0 KB) ( 187 )

Copyright © Editorial Board of JOURNAL OF CHINA MEDICAL IMAGING
Supported by:Beijing Magtech