Accuracy of PET/CT on lymph nodes staging in non-small cell lung cancer—a Meta-analysis
ZHANG Xiao-ying1, HAN Bing2, HOU Yue-fang3, WU Wei1, ZHOU Bao-sen1
1. Department of Epidemiology, College of Public Health, China Medical University, Shenyang 110001, China;2. Department of Ultrasound, Shengjing Hospital Affiliated to China Medical University, Shenyang 110004, China;3. Faculty of Information Management and Information System(Medicine), China Medical University, Shenyang 110001, China
Abstract：Objective: To estimate the diagnostic accuracy of PET/CT for lymph nodes staging in patient with non-small-cell lung cancer using a Meta-analysis with the gold standard of pathological results． Materials and Methods: Search in the studies in English literature in PubMed and Chinese CBM database between 1999 and 2007． Criteria for inclusion and exclusion were according to the criteria of diagnostic research published by Cochrane center． Characteristics of the included studies were evaluated． Subsequently pooled weighted sensitivity, specificity, positive predictive value, negative predictive value were analyzed, and the corresponding 95%CI were calculated． Summary receiver operating characteristic(SROC) curve was performed and the area under the curve(AUC) was calculated． Finally, a sensitivity analysis was performed． Results: Altogether 13 articles that met the standard were included． The pooled weighted sensitivity was 84％ respectively and the pooled weighted specificity was 87％． The area under SROC curve was 90.84％． Conclusion: PET/CT is an accurate noninvasive imaging test for staging of lymph nodes in patient with non-small cell lung cancer, with high sensitivity and specificity．
2009, Vol. 20 
