The relationship between maxillofacial imaging distribution characteristics in 99mTc-MDP whole-body bone scanning and skull base invasion in nasopharyngeal carcinoma
LI Wei, ZHANG Ru-sen, LIU Feng, LU Bin-gui, FU Wen-hai
Cancer Hospital of Guangzhou Medical University, Guangzhou 510095, China
Abstract：Objective: To analyse the relationship between maxillofacial imaging distribution characteristics in 99mTc-MDP whole-body bone scanning and skull base invasion in nasopharyngeal carcinoma(NPC) and detect its formation reasons by using SPECT/CT. Methods: Ninety-three patients of NPC underwent 99mTc-MDP whole-body bone scanning and nasopharyngeal SPECT/CT bone scanning before treatment. In the maxillofacial imaging of whole-body bone scanning, a pentagram region with slightly higher radioactivity distribution than skull base was chosen. Except for 2 corners of the pentagram, the rest part was divided into 6 parts, including top part, left connecting part, right connecting part, left shoulder part, right shoulder part and bottom part. Abnormal radioactive concentration in these 6 parts was recorded and made comparisons between them. The SPECT/CT and clinical data were considered as the qualitative standard of skull base invasion. Then the relationship between radioactive concentration distribution characteristics of maxillofacial 6 parts and skull base invasion were analyzed. Results: Eighty-nine cases with 177 lesions were shown radioactive concentration and four cases without in ninety-three cases. Thirty-seven cases with one lesion, twenty-five cases with two lesions and twenty-seven cases with more than three lesions in eighty-nine cases. Skull base invasion was shown 24, 20, 24 cases respectively among that. There was no significantly statistically difference between the amount of lesions and skull base invasion among the radioactive concentration areas(χ2=5.247, P=0.073). In the 6 parts of abnormal radioactivity, skull base invasion was confirmed in top part 75.00%(27/36), left connecting part 90.00%(27/30), right connecting part 86.49%(32/37), left shoulder part 82.61%(19/23), right shoulder part 85.00%(17/20), bottom part 80.65%(25/31). There was no significantly statistically differences(χ2=5.082, P=0.406). In the parts of highest level radioactivity, skull base invasion was confirmed in top part 36.36%(4/11), left connecting part 94.12%(16/17), right connecting part 89.29%(25/28), left shoulder part 66.67%(6/9), right shoulder part 60.00%(3/5), bottom part 73.68%(14/19). The was significantly difference(χ2=16.616, P=0.005). Left and right connecting parts, left and right shoulder parts were no statistically differences respectively(χ2=0.305, P=0.581; χ2=0.062, P=0.803) and merged into connecting part and shoulder part. There was significantly difference among 4 parts(top part, connecting part, shoulder part, bottom part)(χ2=16.400, P=0.001). There was significant statistically difference among top and connecting part(χ2=16.785, P=0.000), top and bottom part(χ2=4.043, P=0.044), connecting and shoulder part(χ2=5.944, P=0.015), and no significantly differences between the rest. Conclusions: In whole-body bone scanning of NPC, some characteristics of the skull base invasion is shown in maxillofacial imaging. These features are helpful to make diagnosis of skull base invasion.
李 伟;张汝森;刘 枫;卢斌贵;傅文海. 99mTc-MDP全身骨扫描中颌面部示踪剂浓集灶分布与鼻咽癌颅底骨侵犯的关系[J]. , 2015, 26(8): 548-553.
LI Wei;ZHANG Ru-sen;LIU Feng;LU Bin-gui;FU Wen-hai. The relationship between maxillofacial imaging distribution characteristics in 99mTc-MDP whole-body bone scanning and skull base invasion in nasopharyngeal carcinoma. , 2015, 26(8): 548-553.
2015, Vol. 26 
